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1dqo

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==Crystal structure of the cysteine rich domain of mannose receptor complexed with Acetylgalactosamine-4-sulfate==
==Crystal structure of the cysteine rich domain of mannose receptor complexed with Acetylgalactosamine-4-sulfate==
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<StructureSection load='1dqo' size='340' side='right' caption='[[1dqo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='1dqo' size='340' side='right'caption='[[1dqo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1dqo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DQO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1dqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASG:2-DEOXY-2-ACETAMIDO-BETA-D-GALACTOSE-4-SULFATE'>ASG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dqg|1dqg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASG:2-DEOXY-2-ACETAMIDO-BETA-D-GALACTOSE-4-SULFATE'>ASG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqo OCA], [http://pdbe.org/1dqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dqo RCSB], [http://www.ebi.ac.uk/pdbsum/1dqo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqo OCA], [https://pdbe.org/1dqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dqo RCSB], [https://www.ebi.ac.uk/pdbsum/1dqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dqo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MRC1_MOUSE MRC1_MOUSE]] Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
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[https://www.uniprot.org/uniprot/MRC1_MOUSE MRC1_MOUSE] Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dqo_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dqo_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dqo ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Bjorkman, P J]]
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[[Category: Mus musculus]]
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[[Category: Chirino, A J]]
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[[Category: Bjorkman PJ]]
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[[Category: Feizi, T]]
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[[Category: Chirino AJ]]
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[[Category: Leteux, C]]
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[[Category: Feizi T]]
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[[Category: Liu, Y]]
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[[Category: Leteux C]]
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[[Category: Misulovin, Z]]
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[[Category: Liu Y]]
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[[Category: Nussenzweig, M C]]
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[[Category: Misulovin Z]]
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[[Category: Beta trefoil]]
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[[Category: Nussenzweig MC]]
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[[Category: Multilectin receptor]]
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[[Category: Pituitary hormone]]
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[[Category: Sugar binding protein]]
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[[Category: Sulfated carbohydrate]]
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Current revision

Crystal structure of the cysteine rich domain of mannose receptor complexed with Acetylgalactosamine-4-sulfate

PDB ID 1dqo

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