1v0b

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==CRYSTAL STRUCTURE OF THE T198A MUTANT OF PFPK5==
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<StructureSection load='1v0b' size='340' side='right' caption='[[1v0b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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==Crystal structure of the t198a mutant of pfpk5==
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<StructureSection load='1v0b' size='340' side='right'caption='[[1v0b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1v0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V0B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1v0b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V0B FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lch|1lch]], [[1ob3|1ob3]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0b OCA], [http://pdbe.org/1v0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v0b RCSB], [http://www.ebi.ac.uk/pdbsum/1v0b PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0b OCA], [https://pdbe.org/1v0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v0b RCSB], [https://www.ebi.ac.uk/pdbsum/1v0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CDC2H_PLAFK CDC2H_PLAFK]] Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
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[https://www.uniprot.org/uniprot/CDK2H_PLAFK CDK2H_PLAFK] Serine/threonine-protein kinase (PubMed:8844681, PubMed:14604523). Involved in the control of the cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). In schizonts, phosphorylates ORC1 resulting in its dissociation from DNA, relocalization to the cytoplasm and likely its degradation (By similarity).[UniProtKB:P04551]<ref>PMID:14604523</ref> <ref>PMID:8844681</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0b_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0b_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v0b ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plafa]]
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[[Category: Large Structures]]
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[[Category: Burgess, D]]
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[[Category: Plasmodium falciparum]]
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[[Category: Doerig, C]]
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[[Category: Burgess D]]
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[[Category: Endicott, J]]
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[[Category: Doerig C]]
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[[Category: Holton, S]]
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[[Category: Endicott J]]
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[[Category: Merckx, A]]
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[[Category: Holton S]]
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[[Category: Noble, M]]
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[[Category: Merckx A]]
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[[Category: Atp-binding]]
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[[Category: Noble M]]
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[[Category: Cdk]]
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[[Category: Phosphorylation]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the t198a mutant of pfpk5

PDB ID 1v0b

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