This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2dnx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:45, 29 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Solution structure of RSGI RUH-063, an N-terminal domain of Syntaxin 12 from human cDNA==
==Solution structure of RSGI RUH-063, an N-terminal domain of Syntaxin 12 from human cDNA==
-
<StructureSection load='2dnx' size='340' side='right' caption='[[2dnx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2dnx' size='340' side='right'caption='[[2dnx]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2dnx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNX FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2dnx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNX FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STX12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnx OCA], [http://pdbe.org/2dnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dnx RCSB], [http://www.ebi.ac.uk/pdbsum/2dnx PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnx TOPSAN]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnx OCA], [https://pdbe.org/2dnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnx RCSB], [https://www.ebi.ac.uk/pdbsum/2dnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnx ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnx TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/STX12_HUMAN STX12_HUMAN]] SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).
+
[https://www.uniprot.org/uniprot/STX12_HUMAN STX12_HUMAN] SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnx_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnx_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dnx ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
 +
 +
==See Also==
 +
*[[Syntaxin 3D structures|Syntaxin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Abe, T]]
+
[[Category: Large Structures]]
-
[[Category: Hirota, H]]
+
[[Category: Abe T]]
-
[[Category: Muto, Y]]
+
[[Category: Hirota H]]
-
[[Category: Structural genomic]]
+
[[Category: Muto Y]]
-
[[Category: Yokoyama, S]]
+
[[Category: Yokoyama S]]
-
[[Category: Habc domain]]
+
-
[[Category: Left-handed twist]]
+
-
[[Category: Membrane fusion]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Snare]]
+
-
[[Category: Syntaxin]]
+
-
[[Category: Transport protein]]
+
-
[[Category: Up and down three helix bundle]]
+
-
[[Category: Vesicle transport]]
+

Current revision

Solution structure of RSGI RUH-063, an N-terminal domain of Syntaxin 12 from human cDNA

PDB ID 2dnx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools