2d1l

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==Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)==
==Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)==
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<StructureSection load='2d1l' size='340' side='right' caption='[[2d1l]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='2d1l' size='340' side='right'caption='[[2d1l]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2d1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D1L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2d1l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D1L FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2d1k|2d1k]], [[1y2o|1y2o]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mtss1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1l OCA], [https://pdbe.org/2d1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d1l RCSB], [https://www.ebi.ac.uk/pdbsum/2d1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d1l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1l OCA], [http://pdbe.org/2d1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d1l RCSB], [http://www.ebi.ac.uk/pdbsum/2d1l PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MTSS1_MOUSE MTSS1_MOUSE]] Inhibits the nucleation of actin filaments in vitro.<ref>PMID:12482861</ref>
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[https://www.uniprot.org/uniprot/MTSS1_MOUSE MTSS1_MOUSE] Inhibits the nucleation of actin filaments in vitro.<ref>PMID:12482861</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/2d1l_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/2d1l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d1l ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Chereau, D]]
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[[Category: Mus musculus]]
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[[Category: Dominguez, R]]
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[[Category: Chereau D]]
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[[Category: Ferron, F]]
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[[Category: Dominguez R]]
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[[Category: Kerff, F]]
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[[Category: Ferron F]]
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[[Category: Lee, S H]]
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[[Category: Kerff F]]
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[[Category: Actin binding]]
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[[Category: Lee SH]]
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[[Category: Imd]]
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[[Category: Irsp53]]
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[[Category: Protein binding]]
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Current revision

Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)

PDB ID 2d1l

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