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1wuv
From Proteopedia
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==Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin== | ==Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin== | ||
| - | <StructureSection load='1wuv' size='340' side='right' caption='[[1wuv]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='1wuv' size='340' side='right'caption='[[1wuv]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [https://pdbe.org/1wuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [https://www.ebi.ac.uk/pdbsum/1wuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wuv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wuv_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wuv_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wuv ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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==See Also== | ==See Also== | ||
| - | *[[Concanavalin | + | *[[Concanavalin 3D structures|Concanavalin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Canavalia gladiata]] | [[Category: Canavalia gladiata]] | ||
| - | [[Category: Azevedo | + | [[Category: Large Structures]] |
| - | [[Category: Canduri | + | [[Category: Azevedo Jr WF]] |
| - | [[Category: Cardoso | + | [[Category: Canduri F]] |
| - | [[Category: Cavada | + | [[Category: Cardoso ALH]] |
| - | [[Category: Delatorre | + | [[Category: Cavada BS]] |
| - | [[Category: Freitas | + | [[Category: Delatorre P]] |
| - | [[Category: Moreno | + | [[Category: Freitas BT]] |
| - | [[Category: Rocha | + | [[Category: Moreno FBMB]] |
| - | [[Category: Sampaio | + | [[Category: Rocha BAM]] |
| - | [[Category: Souza | + | [[Category: Sampaio AH]] |
| - | + | [[Category: Souza EP]] | |
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Current revision
Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin
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