2heh

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[[Image:2heh.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of the KIF2C motor domain==
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|PDB= 2heh |SIZE=350|CAPTION= <scene name='initialview01'>2heh</scene>, resolution 2.15&Aring;
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<StructureSection load='2heh' size='340' side='right'caption='[[2heh]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene>
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<table><tr><td colspan='2'>[[2heh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEH FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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|GENE= KIF2C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2heh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2heh OCA], [https://pdbe.org/2heh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2heh RCSB], [https://www.ebi.ac.uk/pdbsum/2heh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2heh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KIF2C_HUMAN KIF2C_HUMAN] In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.<ref>PMID:19060894</ref> <ref>PMID:21820309</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2heh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2heh ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of the KIF2C motor domain (CASP Target)'''
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==See Also==
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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== References ==
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==About this Structure==
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<references/>
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2HEH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEH OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Landry, R.]]
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[[Category: Landry R]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Shen Y]]
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[[Category: Shen, Y.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Wang J]]
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[[Category: Wang, J.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: ADP]]
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[[Category: MG]]
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[[Category: UNX]]
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[[Category: adp]]
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[[Category: kinesin]]
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[[Category: motor domain]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:15:04 2008''
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Current revision

Crystal Structure of the KIF2C motor domain

PDB ID 2heh

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OCA

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