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1kzf

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==Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI==
==Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI==
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<StructureSection load='1kzf' size='340' side='right' caption='[[1kzf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='1kzf' size='340' side='right'caption='[[1kzf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1kzf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aplanobacter_stawarti"_(smith_1898)_mcculloch_1918 "aplanobacter stawarti" (smith 1898) mcculloch 1918]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KZF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1kzf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pantoea_stewartii_subsp._stewartii Pantoea stewartii subsp. stewartii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k4j|1k4j]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EsaI/EsaR gene cluster ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=66271 "Aplanobacter stawarti" (Smith 1898) McCulloch 1918])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzf OCA], [https://pdbe.org/1kzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kzf RCSB], [https://www.ebi.ac.uk/pdbsum/1kzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzf OCA], [http://pdbe.org/1kzf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kzf RCSB], [http://www.ebi.ac.uk/pdbsum/1kzf PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ESAI_PANSE ESAI_PANSE]] Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L-homoserine lactone), an autoinducer molecule which binds to EsaR. OHHL is necessary for biosynthesis of EPS virulence factor (extracellular heteropolysaccharide) which plays a role in the development of Stewart's wilt on sweet corn.
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[https://www.uniprot.org/uniprot/ESAI_PANSE ESAI_PANSE] Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L-homoserine lactone), an autoinducer molecule which binds to EsaR. OHHL is necessary for biosynthesis of EPS virulence factor (extracellular heteropolysaccharide) which plays a role in the development of Stewart's wilt on sweet corn.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzf_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzf_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kzf ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bodman, S Beck von]]
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[[Category: Large Structures]]
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[[Category: Churchill, M E.A]]
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[[Category: Pantoea stewartii subsp. stewartii]]
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[[Category: Minogue, T D]]
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[[Category: Beck von Bodman S]]
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[[Category: Val, D L]]
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[[Category: Churchill MEA]]
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[[Category: Watson, W T]]
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[[Category: Minogue TD]]
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[[Category: Acylhomoserine lactone]]
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[[Category: Val DL]]
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[[Category: Alpha-beta]]
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[[Category: Watson WT]]
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[[Category: Autoinducer synthase]]
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[[Category: Bacterial pathogenesis]]
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[[Category: Ligase]]
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[[Category: Quorum sensing]]
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Current revision

Crystal Structure of the Acyl-homoserine Lactone Synthase, EsaI

PDB ID 1kzf

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