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2qz6

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==First crystal structure of a psychrophile class C beta-lactamase==
==First crystal structure of a psychrophile class C beta-lactamase==
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<StructureSection load='2qz6' size='340' side='right' caption='[[2qz6]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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<StructureSection load='2qz6' size='340' side='right'caption='[[2qz6]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2qz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QZ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2qz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QZ6 FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qz6 OCA], [http://pdbe.org/2qz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2qz6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qz6 OCA], [https://pdbe.org/2qz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2qz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qz6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AMPC_PSEFL AMPC_PSEFL]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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[https://www.uniprot.org/uniprot/AMPC_PSEFL AMPC_PSEFL] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/2qz6_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/2qz6_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qz6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
[[Category: Pseudomonas fluorescens]]
[[Category: Pseudomonas fluorescens]]
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[[Category: Charlier, P]]
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[[Category: Charlier P]]
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[[Category: Kerff, F]]
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[[Category: Kerff F]]
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[[Category: Massant, J]]
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[[Category: Massant J]]
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[[Category: Michaux, C]]
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[[Category: Michaux C]]
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[[Category: Wouters, J]]
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[[Category: Wouters J]]
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[[Category: Antibiotic resistance]]
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[[Category: Class c beta-lactamase]]
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[[Category: Cold adaptation]]
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[[Category: Hydrolase]]
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[[Category: Psychrophile]]
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Current revision

First crystal structure of a psychrophile class C beta-lactamase

PDB ID 2qz6

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