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2l4z

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==NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82)==
==NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82)==
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<StructureSection load='2l4z' size='340' side='right' caption='[[2l4z]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l4z' size='340' side='right'caption='[[2l4z]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L4Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m3v|1m3v]], [[1rut|1rut]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTIP, LMO4, RBBP8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4z OCA], [https://pdbe.org/2l4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4z RCSB], [https://www.ebi.ac.uk/pdbsum/2l4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4z OCA], [http://pdbe.org/2l4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l4z RCSB], [http://www.ebi.ac.uk/pdbsum/2l4z PDBsum]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/COM1_HUMAN COM1_HUMAN]] Seckel syndrome. Defects in RBBP8 are a cause of Seckel syndrome type 2 (SCKL2) [MIM:[http://omim.org/entry/606744 606744]]. SCKL2 is a rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.<ref>PMID:21998596</ref> Defects in RBBP8 are a cause of Jawad disease (JWDS) [MIM:[http://omim.org/entry/251255 251255]]. JWDS is a syndrome characterized by congenital microcephaly, moderately severe mental retardation, and symmetrical digital anomalies. Digital malformations of variable degree inclued hallux valgus, syndactyly of toes 4 and 5, short fifth fingers, single flexion crease of fifth fingers, polydactyly and synpolydactyly.<ref>PMID:21998596</ref> Note=Genetic variability in RBBP8 is noted as a factor in BRCA1-associated breast cancer risk. Exhibits sensitivity to tamoxifen in certain breast cancer cell lines.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/COM1_HUMAN COM1_HUMAN]] Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.<ref>PMID:10764811</ref> <ref>PMID:10910365</ref> <ref>PMID:15485915</ref> <ref>PMID:16818604</ref> <ref>PMID:16581787</ref> <ref>PMID:17965729</ref> <ref>PMID:19202191</ref> <ref>PMID:19759395</ref> <ref>PMID:20064462</ref> <ref>PMID:20829486</ref>
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[https://www.uniprot.org/uniprot/LMO4_MOUSE LMO4_MOUSE] Probable transcriptional factor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Kwan, A H]]
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[[Category: Large Structures]]
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[[Category: Liew, C]]
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[[Category: Mus musculus]]
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[[Category: Matthews, J M]]
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[[Category: Kwan AH]]
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[[Category: Stokes, P H]]
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[[Category: Liew C]]
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[[Category: Hydrolase]]
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[[Category: Matthews JM]]
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[[Category: Lim domain]]
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[[Category: Stokes PH]]
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[[Category: Lim-interaction domain]]
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[[Category: Lim-only protein]]
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[[Category: Lmo4]]
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[[Category: Metal binding protein]]
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[[Category: Protein-protein interaction]]
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[[Category: Rbbp8/ctip]]
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Current revision

NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82)

PDB ID 2l4z

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