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2j23

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==CROSS-REACTIVITY AND CRYSTAL STRUCTURE OF MALASSEZIA SYMPODIALIS THIOREDOXIN (MALA S 13), A MEMBER OF A NEW PAN-ALLERGEN FAMILY==
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<StructureSection load='2j23' size='340' side='right' caption='[[2j23]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
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==Cross-reactivity and crystal structure of Malassezia sympodialis Thioredoxin (Mala s 13), a member of a new pan-allergen family==
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<StructureSection load='2j23' size='340' side='right'caption='[[2j23]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2j23]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J23 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2j23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J23 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j23 OCA], [http://pdbe.org/2j23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j23 RCSB], [http://www.ebi.ac.uk/pdbsum/2j23 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j23 OCA], [https://pdbe.org/2j23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j23 RCSB], [https://www.ebi.ac.uk/pdbsum/2j23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j23 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THIO_MALSM THIO_MALSM] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.<ref>PMID:17182577</ref> <ref>PMID:19032234</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/2j23_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/2j23_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j23 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Thioredoxin|Thioredoxin]]
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 96803]]
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[[Category: Large Structures]]
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[[Category: Crameri, R]]
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[[Category: Malassezia sympodialis]]
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[[Category: Glaser, A G]]
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[[Category: Crameri R]]
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[[Category: Limacher, A]]
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[[Category: Glaser AG]]
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[[Category: Meier, C]]
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[[Category: Limacher A]]
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[[Category: Scapozza, L]]
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[[Category: Meier C]]
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[[Category: Allergen]]
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[[Category: Scapozza L]]
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[[Category: Autoreactivity]]
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[[Category: Cross-reactivity]]
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[[Category: Epitope]]
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[[Category: Fungi]]
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[[Category: Ige]]
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[[Category: Immune protein]]
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[[Category: Malassezia sympodiali]]
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[[Category: Thioredoxin]]
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Current revision

Cross-reactivity and crystal structure of Malassezia sympodialis Thioredoxin (Mala s 13), a member of a new pan-allergen family

PDB ID 2j23

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