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1l2z

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==CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide==
==CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide==
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<StructureSection load='1l2z' size='340' side='right' caption='[[1l2z]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='1l2z' size='340' side='right'caption='[[1l2z]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1l2z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1l2z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2Z FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gyf|1gyf]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD2BP2 (amino acids 280-341) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2z OCA], [https://pdbe.org/1l2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2z RCSB], [https://www.ebi.ac.uk/pdbsum/1l2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2z OCA], [http://pdbe.org/1l2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l2z RCSB], [http://www.ebi.ac.uk/pdbsum/1l2z PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD2_HUMAN CD2_HUMAN]] CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
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[https://www.uniprot.org/uniprot/CD2B2_HUMAN CD2B2_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2z_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2z_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2z ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Freund, C]]
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[[Category: Large Structures]]
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[[Category: Kuhne, R]]
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[[Category: Freund C]]
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[[Category: Park, S]]
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[[Category: Kuhne R]]
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[[Category: Reinherz, E L]]
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[[Category: Park S]]
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[[Category: Wagner, G]]
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[[Category: Reinherz EL]]
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[[Category: Yang, H]]
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[[Category: Wagner G]]
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[[Category: Cd2]]
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[[Category: Yang H]]
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[[Category: Cd2bp2]]
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[[Category: Gyf domain]]
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[[Category: Peptide binding-signaling protein complex]]
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[[Category: Proline-rich peptide]]
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[[Category: Protein-protein interaction]]
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Current revision

CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide

PDB ID 1l2z

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