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2p74

From Proteopedia

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[[Image:2p74.jpg|left|200px]]
 
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{{Structure
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==CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution==
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|PDB= 2p74 |SIZE=350|CAPTION= <scene name='initialview01'>2p74</scene>, resolution 0.88&Aring;
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<StructureSection load='2p74' size='340' side='right'caption='[[2p74]], [[Resolution|resolution]] 0.88&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=K:POTASSIUM ION'>K</scene>
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<table><tr><td colspan='2'>[[2p74]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P74 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.88&#8491;</td></tr>
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|GENE= CTX-M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p74 OCA], [https://pdbe.org/2p74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p74 RCSB], [https://www.ebi.ac.uk/pdbsum/2p74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p74 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9L5C8_ECOLX Q9L5C8_ECOLX]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p74_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p74 ConSurf].
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<div style="clear:both"></div>
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'''CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution'''
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2P74 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P74 OCA].
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==Reference==
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The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution., Chen Y, Bonnet R, Shoichet BK, J Am Chem Soc. 2007 May 2;129(17):5378-80. Epub 2007 Apr 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17408273 17408273]
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bonnet, R.]]
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[[Category: Bonnet R]]
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[[Category: Chen, Y.]]
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[[Category: Chen Y]]
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[[Category: Shoichet, B K.]]
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[[Category: Shoichet BK]]
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[[Category: K]]
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[[Category: PO4]]
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[[Category: acylation]]
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[[Category: beta-lactamase]]
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[[Category: ctx-m]]
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[[Category: esbl]]
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[[Category: ultra-high resolution]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:37:21 2008''
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Current revision

CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution

PDB ID 2p74

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