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2puz

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[[Image:2puz.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of Imidazolonepropionase from Agrobacterium tumefaciens with bound product N-formimino-L-Glutamate==
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|PDB= 2puz |SIZE=350|CAPTION= <scene name='initialview01'>2puz</scene>, resolution 1.83&Aring;
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<StructureSection load='2puz' size='340' side='right'caption='[[2puz]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=NIG:N-(IMINOMETHYL)-L-GLUTAMIC ACID'>NIG</scene>
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<table><tr><td colspan='2'>[[2puz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_fabrum_str._C58 Agrobacterium fabrum str. C58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PUZ FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Imidazolonepropionase Imidazolonepropionase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.7 3.5.2.7]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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|GENE= hutI, Atu3934, AGR_L_1824 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=358 Agrobacterium tumefaciens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NIG:N-(IMINOMETHYL)-L-GLUTAMIC+ACID'>NIG</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2puz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2puz OCA], [https://pdbe.org/2puz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2puz RCSB], [https://www.ebi.ac.uk/pdbsum/2puz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2puz ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2puz TOPSAN]</span></td></tr>
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</table>
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'''Crystal structure of Imidazolonepropionase from Agrobacterium tumefaciens with bound product N-formimino-L-Glutamate'''
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== Function ==
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[https://www.uniprot.org/uniprot/HUTI_AGRFC HUTI_AGRFC] Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.[HAMAP-Rule:MF_00372]
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2PUZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUZ OCA].
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Check<jmol>
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<jmolCheckbox>
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==Reference==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pu/2puz_consurf.spt"</scriptWhenChecked>
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X-ray structure of imidazolonepropionase from Agrobacterium tumefaciens at 1.87 A resolution., Tyagi R, Kumaran D, Burley SK, Swaminathan S, Proteins. 2007 Nov 15;69(3):652-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17640072 17640072]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Agrobacterium tumefaciens]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Imidazolonepropionase]]
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</jmolCheckbox>
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[[Category: Single protein]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2puz ConSurf].
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[[Category: Burley, S K.]]
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<div style="clear:both"></div>
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[[Category: Eswaramoorthy, S.]]
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__TOC__
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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</StructureSection>
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[[Category: Swaminathan, S.]]
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[[Category: Agrobacterium fabrum str. C58]]
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[[Category: Tyagi, R.]]
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[[Category: Large Structures]]
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[[Category: CL]]
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[[Category: Burley SK]]
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[[Category: FE]]
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[[Category: Eswaramoorthy S]]
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[[Category: MG]]
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[[Category: Swaminathan S]]
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[[Category: NIG]]
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[[Category: Tyagi R]]
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[[Category: 9252b]]
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[[Category: hydrolase]]
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[[Category: imidazolonepropionase]]
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[[Category: n-formimino-l-glutamate]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: product-bound]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:41:08 2008''
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Current revision

Crystal structure of Imidazolonepropionase from Agrobacterium tumefaciens with bound product N-formimino-L-Glutamate

PDB ID 2puz

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