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| | ==GROWTH-BLOCKING PEPTIDE (GBP) FROM PSEUDALETIA SEPARATA== | | ==GROWTH-BLOCKING PEPTIDE (GBP) FROM PSEUDALETIA SEPARATA== |
| - | <StructureSection load='1bqf' size='340' side='right' caption='[[1bqf]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''> | + | <StructureSection load='1bqf' size='340' side='right'caption='[[1bqf]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1bqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotesia_kariyai Cotesia kariyai]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BQF FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1bqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cotesia_kariyai Cotesia kariyai]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BQF FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqf OCA], [http://pdbe.org/1bqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bqf RCSB], [http://www.ebi.ac.uk/pdbsum/1bqf PDBsum]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqf OCA], [https://pdbe.org/1bqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bqf RCSB], [https://www.ebi.ac.uk/pdbsum/1bqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bqf ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/GBP_MYTSE GBP_MYTSE]] Biogenic peptide that prevents the onset of metamorphosis from larva to pupa. Has repressive activity against juvenile hormone esterase. Induces cell proliferation at low concentrations and inhibits it at high concentrations. Mediates the spreading of plasmatocytes to foreign surfaces. May have a role in the regulation of dopamine concentrations.<ref>PMID:10928276</ref> <ref>PMID:11429413</ref> <ref>PMID:9753606</ref> | + | [https://www.uniprot.org/uniprot/GBP_MYTSE GBP_MYTSE] Biogenic peptide that prevents the onset of metamorphosis from larva to pupa. Has repressive activity against juvenile hormone esterase. Induces cell proliferation at low concentrations and inhibits it at high concentrations. Mediates the spreading of plasmatocytes to foreign surfaces. May have a role in the regulation of dopamine concentrations.<ref>PMID:10928276</ref> <ref>PMID:11429413</ref> <ref>PMID:9753606</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Cotesia kariyai]] | | [[Category: Cotesia kariyai]] |
| - | [[Category: Aizawa, T]] | + | [[Category: Large Structures]] |
| - | [[Category: Fujitani, N]] | + | [[Category: Aizawa T]] |
| - | [[Category: Hayakawa, Y]] | + | [[Category: Fujitani N]] |
| - | [[Category: Hikichi, K]] | + | [[Category: Hayakawa Y]] |
| - | [[Category: Kwano, K]] | + | [[Category: Hikichi K]] |
| - | [[Category: Nitta, K]] | + | [[Category: Kwano K]] |
| - | [[Category: Ohkubo, T]] | + | [[Category: Nitta K]] |
| - | [[Category: Ohnishi, A]] | + | [[Category: Ohkubo T]] |
| - | [[Category: Growth factor]]
| + | [[Category: Ohnishi A]] |
| - | [[Category: Hormone-growth factor complex]]
| + | |
| Structural highlights
Function
GBP_MYTSE Biogenic peptide that prevents the onset of metamorphosis from larva to pupa. Has repressive activity against juvenile hormone esterase. Induces cell proliferation at low concentrations and inhibits it at high concentrations. Mediates the spreading of plasmatocytes to foreign surfaces. May have a role in the regulation of dopamine concentrations.[1] [2] [3]
Publication Abstract from PubMed
Growth-blocking peptide (GBP) is an insect growth factor consisting of 25 amino acid residues that retards the development of lepidopteran larvae at high concentration while it stimulates larval growth at low concentration. In this study, we determined the solution structure of GBP by two-dimensional 1H NMR spectroscopy. The structure contains a short segment of double-stranded beta-sheet involving residues 11-13 and 19-21 and a type-II beta-turn in the loop region (residues 8-11), whereas the N and C termini are disordered. This is the first report of the three-dimensional structure of the peptiderigic insect growth factor, and the structure of the well defined region of GBP was found to share similarity with that of the C-terminal domain of the epidermal growth factor (EGF). Because GBP has been reported to stimulate DNA synthesis of not only insect cells but also human keratinocyte cells at the same level with EGF, the structural similarity between GBP and EGF may lead to the interaction of GBP to EGF receptor.
Solution structure of an insect growth factor, growth-blocking peptide.,Aizawa T, Fujitani N, Hayakawa Y, Ohnishi A, Ohkubo T, Kumaki Y, Kawano K, Hikichi K, Nitta K J Biol Chem. 1999 Jan 22;274(4):1887-90. PMID:9890941[4]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Hayakawa Y, Ohnishi A, Mizoguchi A, Yamashika C. Distribution of growth-blocking peptide in the insect central nervous tissue. Cell Tissue Res. 2000 Jun;300(3):459-64. PMID:10928276
- ↑ Aizawa T, Hayakawa Y, Ohnishi A, Fujitani N, Clark KD, Strand MR, Miura K, Koganesawa N, Kumaki Y, Demura M, Nitta K, Kawano K. Structure and activity of the insect cytokine growth-blocking peptide. Essential regions for mitogenic and hemocyte-stimulating activities are separate. J Biol Chem. 2001 Aug 24;276(34):31813-8. Epub 2001 Jun 27. PMID:11429413 doi:http://dx.doi.org/10.1074/jbc.M105251200
- ↑ Hayakawa Y, Ohnishi A. Cell growth activity of growth-blocking peptide. Biochem Biophys Res Commun. 1998 Sep 18;250(2):194-9. PMID:9753606 doi:http://dx.doi.org/10.1006/bbrc.1998.8959
- ↑ Aizawa T, Fujitani N, Hayakawa Y, Ohnishi A, Ohkubo T, Kumaki Y, Kawano K, Hikichi K, Nitta K. Solution structure of an insect growth factor, growth-blocking peptide. J Biol Chem. 1999 Jan 22;274(4):1887-90. PMID:9890941
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