1u2h

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==X-ray Structure of the N-terminally truncated human APEP-1==
==X-ray Structure of the N-terminally truncated human APEP-1==
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<StructureSection load='1u2h' size='340' side='right' caption='[[1u2h]], [[Resolution|resolution]] 0.96&Aring;' scene=''>
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<StructureSection load='1u2h' size='340' side='right'caption='[[1u2h]], [[Resolution|resolution]] 0.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1u2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U2H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1u2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U2H FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Arotic Preferentially Expressed Gene 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.96&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u2h OCA], [http://pdbe.org/1u2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u2h RCSB], [http://www.ebi.ac.uk/pdbsum/1u2h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u2h OCA], [https://pdbe.org/1u2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u2h RCSB], [https://www.ebi.ac.uk/pdbsum/1u2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u2h ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SPEG_HUMAN SPEG_HUMAN]] Autosomal recessive centronuclear myopathy. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/SPEG_HUMAN SPEG_HUMAN] Autosomal recessive centronuclear myopathy. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPEG_HUMAN SPEG_HUMAN]] Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
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[https://www.uniprot.org/uniprot/SPEG_HUMAN SPEG_HUMAN] Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u2/1u2h_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u2/1u2h_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u2h ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bussow, K]]
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[[Category: Large Structures]]
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[[Category: Gotz, F]]
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[[Category: Bussow K]]
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[[Category: Heinemann, U]]
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[[Category: Gotz F]]
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[[Category: Manjasetty, B A]]
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[[Category: Heinemann U]]
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[[Category: Niesen, F H]]
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[[Category: Manjasetty BA]]
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[[Category: Roske, Y]]
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[[Category: Niesen FH]]
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[[Category: Scheich, C]]
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[[Category: Roske Y]]
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[[Category: Arterial smooth muscle cell]]
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[[Category: Scheich C]]
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[[Category: Atherosclerosis]]
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[[Category: Contractile protein]]
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[[Category: Homophilic adhesion]]
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[[Category: Ig-fold i-set]]
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[[Category: Rgd motif]]
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[[Category: Structural genomic]]
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Current revision

X-ray Structure of the N-terminally truncated human APEP-1

PDB ID 1u2h

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