2z5f

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[[Image:2z5f.jpg|left|200px]]
 
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{{Structure
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==Human sulfotransferase Sult1b1 in complex with PAP==
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|PDB= 2z5f |SIZE=350|CAPTION= <scene name='initialview01'>2z5f</scene>, resolution 2.10&Aring;
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<StructureSection load='2z5f' size='340' side='right'caption='[[2z5f]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>
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<table><tr><td colspan='2'>[[2z5f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xv1 1xv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5F FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= SULT1B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5f OCA], [https://pdbe.org/2z5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5f RCSB], [https://www.ebi.ac.uk/pdbsum/2z5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ST1B1_HUMAN ST1B1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.<ref>PMID:9443824</ref> <ref>PMID:9463486</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5f ConSurf].
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<div style="clear:both"></div>
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'''Human sulfotransferase Sult1b1 in complex with PAP'''
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==See Also==
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2Z5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1XV1. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5F OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)., Dombrovski L, Dong A, Bochkarev A, Plotnikov AN, Proteins. 2006 Sep 1;64(4):1091-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16804942 16804942]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Dombrovski, L.]]
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[[Category: Dombrovski L]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau P]]
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[[Category: Pegasova, T.]]
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[[Category: Pegasova T]]
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[[Category: Plotnikov, A N.]]
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[[Category: Plotnikov AN]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Wu H]]
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[[Category: Wu, H.]]
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[[Category: A3P]]
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[[Category: pap]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: sulfotransferase]]
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[[Category: sult]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:56:38 2008''
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Current revision

Human sulfotransferase Sult1b1 in complex with PAP

PDB ID 2z5f

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