3b4c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:58, 14 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3b4c.gif|left|200px]]
 
-
{{Structure
+
==T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage==
-
|PDB= 3b4c |SIZE=350|CAPTION= <scene name='initialview01'>3b4c</scene>, resolution 3.0&Aring;
+
<StructureSection load='3b4c' size='340' side='right'caption='[[3b4c]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=GLP:GLUCOSAMINE+6-PHOSPHATE'>GLP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=3AD:3&#39;-DEOXYADENOSINE'>3AD</scene>
+
<table><tr><td colspan='2'>[[3b4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B4C FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AD:3-DEOXYADENOSINE'>3AD</scene>, <scene name='pdbligand=GLP:GLUCOSAMINE+6-PHOSPHATE'>GLP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4c OCA], [https://pdbe.org/3b4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b4c RCSB], [https://www.ebi.ac.uk/pdbsum/3b4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4c ProSAT]</span></td></tr>
 +
</table>
-
'''T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage'''
+
==See Also==
-
 
+
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The glmS ribozyme is a catalytic riboswitch that is activated for endonucleolytic cleavage by the coenzyme glucosamine-6-phosphate. Using kinetic assays and X-ray crystallography, we identify an active-site mutation of a conserved guanine that abolishes catalysis without perturbing coenzyme binding. Our results provide evidence that coenzyme function requires a specific nucleobase to interact with the nucleophile of the cleavage reaction.
+
[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
-
 
+
[[Category: Large Structures]]
-
==About this Structure==
+
[[Category: Ferre-D'Amare AR]]
-
3B4C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermoanaerobacter_tengcongensis Thermoanaerobacter tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4C OCA].
+
[[Category: Klein DJ]]
-
 
+
-
==Reference==
+
-
Essential role of an active-site guanine in glmS ribozyme catalysis., Klein DJ, Been MD, Ferre-D'Amare AR, J Am Chem Soc. 2007 Dec 5;129(48):14858-9. Epub 2007 Nov 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17990888 17990888]
+
-
[[Category: Protein complex]]
+
-
[[Category: Thermoanaerobacter tengcongensis]]
+
-
[[Category: Amare, A R.Ferre-D.]]
+
-
[[Category: Klein, D J.]]
+
-
[[Category: 3AD]]
+
-
[[Category: GLP]]
+
-
[[Category: MG]]
+
-
[[Category: glucosamine-6-phosphate]]
+
-
[[Category: riboswitch]]
+
-
[[Category: ribozyme]]
+
-
[[Category: rna]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:58:14 2008''
+

Current revision

T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage

PDB ID 3b4c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3b4c"
Personal tools