1w7k

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==E.COLI FOLC IN COMPLEX WITH ADP, WITHOUT FOLATE SUBSTRATE==
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<StructureSection load='1w7k' size='340' side='right' caption='[[1w7k]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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==E.coli FolC in complex with ADP, without folate substrate==
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<StructureSection load='1w7k' size='340' side='right'caption='[[1w7k]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W7K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w78|1w78]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [https://pdbe.org/1w7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [https://www.ebi.ac.uk/pdbsum/1w7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w7k ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [http://pdbe.org/1w7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [http://www.ebi.ac.uk/pdbsum/1w7k PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FOLC_ECOLI FOLC_ECOLI]] Conversion of folates to polyglutamate derivatives.
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[https://www.uniprot.org/uniprot/FOLC_ECOLI FOLC_ECOLI] Conversion of folates to polyglutamate derivatives.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/1w7k_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/1w7k_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w7k ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</div>
</div>
<div class="pdbe-citations 1w7k" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1w7k" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Folylpolyglutamate synthase|Folylpolyglutamate synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Dihydrofolate synthase]]
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[[Category: Large Structures]]
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[[Category: Bamas-Jacques, N]]
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[[Category: Bamas-Jacques N]]
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[[Category: Debousker, G]]
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[[Category: Debousker G]]
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[[Category: Mathieu, M]]
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[[Category: Mathieu M]]
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[[Category: Mikol, V]]
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[[Category: Mikol V]]
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[[Category: Vincent, S]]
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[[Category: Vincent S]]
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[[Category: Viviani, F]]
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[[Category: Viviani F]]
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[[Category: Atp-binding]]
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[[Category: Dhf]]
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[[Category: Folate biosynthesis]]
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[[Category: Folc]]
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[[Category: Ligase]]
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[[Category: Multifunctional enzyme]]
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[[Category: Synthase]]
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Current revision

E.coli FolC in complex with ADP, without folate substrate

PDB ID 1w7k

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