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2mh3

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==NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1==
==NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1==
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<StructureSection load='2mh3' size='340' side='right' caption='[[2mh3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mh3' size='340' side='right'caption='[[2mh3]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MH3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mh3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MH3 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HES1, BHLHB39, HL, HRY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mh3 OCA], [http://pdbe.org/2mh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mh3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mh3 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mh3 OCA], [https://pdbe.org/2mh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mh3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mh3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN]] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref>
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[https://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Boelens, R]]
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[[Category: Large Structures]]
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[[Category: Coglievina, M]]
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[[Category: Boelens R]]
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[[Category: Pintar, A]]
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[[Category: Coglievina M]]
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[[Category: Pongor, S]]
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[[Category: Pintar A]]
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[[Category: Popovic, M]]
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[[Category: Pongor S]]
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[[Category: Wienk, H]]
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[[Category: Popovic M]]
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[[Category: Bhlh]]
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[[Category: Wienk H]]
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[[Category: Dna binding protein]]
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Current revision

NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1

PDB ID 2mh3

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