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2okc

From Proteopedia

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[[Image:2okc.gif|left|200px]]
 
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{{Structure
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==Crystal structure of Type I restriction enzyme StySJI M protein (NP_813429.1) from Bacteroides thetaiotaomicron VPI-5482 at 2.20 A resolution==
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|PDB= 2okc |SIZE=350|CAPTION= <scene name='initialview01'>2okc</scene>, resolution 2.20&Aring;
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<StructureSection load='2okc' size='340' side='right'caption='[[2okc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
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<table><tr><td colspan='2'>[[2okc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKC FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Site-specific_DNA-methyltransferase_(adenine-specific) Site-specific DNA-methyltransferase (adenine-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.72 2.1.1.72] </span>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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|GENE= NP_813429.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=818 Bacteroides thetaiotaomicron])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okc OCA], [https://pdbe.org/2okc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okc RCSB], [https://www.ebi.ac.uk/pdbsum/2okc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okc ProSAT], [https://www.topsan.org/Proteins/JCSG/2okc TOPSAN]</span></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02384 N6_Mtase]</span>
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okc OCA], [http://www.ebi.ac.uk/pdbsum/2okc PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2okc RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/T1M_BACTN T1M_BACTN] Methylation of specific adenine residues; required for both restriction and modification activities.
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== Evolutionary Conservation ==
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'''Crystal structure of Type I restriction enzyme StySJI M protein (NP_813429.1) from Bacteriodes thetaiotaomicron VPI-5482 at 2.20 A resolution'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/2okc_consurf.spt"</scriptWhenChecked>
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2OKC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKC OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Bacteroides thetaiotaomicron]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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[[Category: Site-specific DNA-methyltransferase (adenine-specific)]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2okc ConSurf].
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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<div style="clear:both"></div>
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[[Category: jcsg]]
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__TOC__
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[[Category: joint center for structural genomic]]
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</StructureSection>
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[[Category: n-6 dna methylase]]
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[[Category: Bacteroides thetaiotaomicron VPI-5482]]
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[[Category: np_813429 1]]
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[[Category: Large Structures]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomic]]
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[[Category: type i restriction enzyme stysji m protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Mar 25 23:32:34 2008''
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Current revision

Crystal structure of Type I restriction enzyme StySJI M protein (NP_813429.1) from Bacteroides thetaiotaomicron VPI-5482 at 2.20 A resolution

PDB ID 2okc

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