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2fht

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==Crystal Structure of Viral Macrophage Inflammatory Protein-II==
==Crystal Structure of Viral Macrophage Inflammatory Protein-II==
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<StructureSection load='2fht' size='340' side='right' caption='[[2fht]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='2fht' size='340' side='right'caption='[[2fht]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2fht]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FHT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2fht]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_8_strain_GK18 Human herpesvirus 8 strain GK18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FHT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fht OCA], [http://pdbe.org/2fht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fht RCSB], [http://www.ebi.ac.uk/pdbsum/2fht PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fht OCA], [https://pdbe.org/2fht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fht RCSB], [https://www.ebi.ac.uk/pdbsum/2fht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fht ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VMI2_HHV8P VMI2_HHV8P]] Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
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[https://www.uniprot.org/uniprot/VMI2_HHV8P VMI2_HHV8P] Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fht_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fht_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fht ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cao, R]]
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[[Category: Human herpesvirus 8 strain GK18]]
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[[Category: Dong, C Z]]
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[[Category: Large Structures]]
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[[Category: Gao, Y G]]
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[[Category: Cao R]]
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[[Category: Huang, Z]]
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[[Category: Dong CZ]]
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[[Category: Kumar, S]]
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[[Category: Gao YG]]
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[[Category: Li, Y]]
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[[Category: Huang Z]]
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[[Category: Liu, D]]
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[[Category: Kumar S]]
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[[Category: Wilson, S R]]
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[[Category: Li Y]]
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[[Category: Anti-hiv]]
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[[Category: Liu D]]
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[[Category: Chemokine]]
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[[Category: Wilson SR]]
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[[Category: Herpesvirus]]
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Current revision

Crystal Structure of Viral Macrophage Inflammatory Protein-II

PDB ID 2fht

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