1ywi

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==Structure of the FBP11WW1 domain complexed to the peptide APPTPPPLPP==
==Structure of the FBP11WW1 domain complexed to the peptide APPTPPPLPP==
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<StructureSection load='1ywi' size='340' side='right' caption='[[1ywi]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='1ywi' size='340' side='right'caption='[[1ywi]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ywi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YWI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ywi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YWI FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f8a|1f8a]], [[1i5h|1i5h]], [[1eg4|1eg4]], [[1cka|1cka]], [[1o6w|1o6w]], [[1ywj|1ywj]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywi OCA], [http://pdbe.org/1ywi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ywi RCSB], [http://www.ebi.ac.uk/pdbsum/1ywi PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ywi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywi OCA], [https://pdbe.org/1ywi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ywi RCSB], [https://www.ebi.ac.uk/pdbsum/1ywi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ywi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PR40A_HUMAN PR40A_HUMAN]] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.<ref>PMID:21834987</ref>
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[https://www.uniprot.org/uniprot/PR40A_HUMAN PR40A_HUMAN] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.<ref>PMID:21834987</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/1ywi_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/1ywi_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ywi ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Aido-Machado, R]]
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[[Category: Large Structures]]
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[[Category: Boehm, G]]
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[[Category: Aido-Machado R]]
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[[Category: Oschkinat, H]]
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[[Category: Boehm G]]
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[[Category: Otte, L]]
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[[Category: Oschkinat H]]
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[[Category: Parthier, C]]
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[[Category: Otte L]]
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[[Category: Pires, J R]]
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[[Category: Parthier C]]
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[[Category: Rudolph, R]]
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[[Category: Pires JR]]
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[[Category: Wiedemann, U]]
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[[Category: Rudolph R]]
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[[Category: Class ii]]
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[[Category: Wiedemann U]]
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[[Category: Proline-rich peptide]]
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[[Category: Protein-protein interaction]]
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[[Category: Structural protein]]
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[[Category: Ww domain]]
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Current revision

Structure of the FBP11WW1 domain complexed to the peptide APPTPPPLPP

PDB ID 1ywi

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OCA

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