|
|
| (3 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| | + | |
| | ==Solution structure of the forkhead domain of Brugia malayi DAF-16a== | | ==Solution structure of the forkhead domain of Brugia malayi DAF-16a== |
| - | <StructureSection load='2mbf' size='340' side='right' caption='[[2mbf]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2mbf' size='340' side='right'caption='[[2mbf]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2mbf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bruma Bruma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBF FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2mbf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBF FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bm1_50095 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6279 BRUMA])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbf OCA], [http://pdbe.org/2mbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mbf RCSB], [http://www.ebi.ac.uk/pdbsum/2mbf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbf OCA], [https://pdbe.org/2mbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbf RCSB], [https://www.ebi.ac.uk/pdbsum/2mbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbf ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| Line 19: |
Line 20: |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bruma]] | + | [[Category: Brugia malayi]] |
| - | [[Category: Casper, S K]] | + | [[Category: Large Structures]] |
| - | [[Category: Peterson, F C]] | + | [[Category: Casper SK]] |
| - | [[Category: Schoeller, S J]] | + | [[Category: Peterson FC]] |
| - | [[Category: Veldkamp, C T]] | + | [[Category: Schoeller SJ]] |
| - | [[Category: Filarial parasite]] | + | [[Category: Veldkamp CT]] |
| - | [[Category: Forkhead]]
| + | |
| - | [[Category: Foxo]]
| + | |
| - | [[Category: Foxo3a]]
| + | |
| - | [[Category: Insulin/igf-1 signaling]]
| + | |
| - | [[Category: Transcription]]
| + | |
| - | [[Category: Winged helix]]
| + | |
| Structural highlights
Publication Abstract from PubMed
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.
The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.,Casper SK, Schoeller SJ, Zgoba DM, Phillips AJ, Morien TJ, Chaffee GR, Sackett PC, Peterson FC, Crossgrove K, Veldkamp CT Proteins. 2014 Oct 9. doi: 10.1002/prot.24701. PMID:25297652[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Casper SK, Schoeller SJ, Zgoba DM, Phillips AJ, Morien TJ, Chaffee GR, Sackett PC, Peterson FC, Crossgrove K, Veldkamp CT. The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a. Proteins. 2014 Oct 9. doi: 10.1002/prot.24701. PMID:25297652 doi:http://dx.doi.org/10.1002/prot.24701
|
