2fqn

<StructureSection load='2fqn' size='340' side='right' caption='[[2fqn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[2fqn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FQN FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fqn OCA], [http://pdbe.org/2fqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fqn RCSB], [http://www.ebi.ac.uk/pdbsum/2fqn PDBsum]</span></td></tr>

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== Publication Abstract from PubMed ==

The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493.

Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.,Kondo J, Urzhumtsev A, Westhof E Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:16452297<ref>PMID:16452297</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2fqn" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Kondo, J]]

[[Category: Urzhumtsev, A]]

[[Category: Westhof, E]]

[[Category: A site]]

[[Category: Decoding site]]

[[Category: Rrna]]