1jr7

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[[Image:1jr7.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF GAB REVEALS OXIDOREDUCTASE FOLD==
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|PDB= 1jr7 |SIZE=350|CAPTION= <scene name='initialview01'>1jr7</scene>, resolution 2.00&Aring;
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<StructureSection load='1jr7' size='340' side='right'caption='[[1jr7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>
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<table><tr><td colspan='2'>[[1jr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jfy 1jfy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR7 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE= GAB; YGAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00250 CAS_like]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr7 OCA], [https://pdbe.org/1jr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr7 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr7 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1jr7 TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr7 OCA], [http://www.ebi.ac.uk/pdbsum/1jr7 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1jr7 RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/GLAH_ECOLI GLAH_ECOLI] Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG) in the stationary phase of E.coli. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Other dicarboxylic acids (oxalate, malonate, succinate, adipate, and pimelate) are not substrates for this enzyme.<ref>PMID:30498244</ref>
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'''CRYSTAL STRUCTURE OF GAB REVEALS OXIDOREDUCTASE FOLD'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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1JR7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry 1JFY. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR7 OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jr7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==Reference==
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<text>to colour the structure by Evolutionary Conservation</text>
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Structural genomics: a pipeline for providing structures for the biologist., Chance MR, Bresnick AR, Burley SK, Jiang JS, Lima CD, Sali A, Almo SC, Bonanno JB, Buglino JA, Boulton S, Chen H, Eswar N, He G, Huang R, Ilyin V, McMahan L, Pieper U, Ray S, Vidal M, Wang LK, Protein Sci. 2002 Apr;11(4):723-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11910018 11910018]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jr7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Lima, C D.]]
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[[Category: Lima CD]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: 2-oxoglutarate]]
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[[Category: antibiotics biosynthesis]]
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[[Category: b-lactam]]
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[[Category: ferrous oxygenase]]
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[[Category: gaba]]
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[[Category: gamma amino-butyric acid metabolism]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: oxidoreductase]]
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[[Category: oxygenase]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 05:54:20 2008''
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Current revision

CRYSTAL STRUCTURE OF GAB REVEALS OXIDOREDUCTASE FOLD

PDB ID 1jr7

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