2f5y
From Proteopedia
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==Crystal Structure of the PDZ Domain from Human RGS-3== | ==Crystal Structure of the PDZ Domain from Human RGS-3== | ||
| - | <StructureSection load='2f5y' size='340' side='right' caption='[[2f5y]], [[Resolution|resolution]] 2.39Å' scene=''> | + | <StructureSection load='2f5y' size='340' side='right'caption='[[2f5y]], [[Resolution|resolution]] 2.39Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5Y FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5y OCA], [https://pdbe.org/2f5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5y RCSB], [https://www.ebi.ac.uk/pdbsum/2f5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5y ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5y_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5y_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f5y ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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| + | ==See Also== | ||
| + | *[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Berridge | + | [[Category: Arrowsmith C]] |
| - | [[Category: Bunkoczi | + | [[Category: Berridge G]] |
| - | [[Category: Burgess | + | [[Category: Bunkoczi G]] |
| - | [[Category: Colebrook | + | [[Category: Burgess N]] |
| - | [[Category: Debreczeni | + | [[Category: Colebrook S]] |
| - | + | [[Category: Debreczeni J]] | |
| - | [[Category: Doyle | + | [[Category: Doyle D]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Elkins | + | [[Category: Elkins J]] |
| - | [[Category: Gorrec | + | [[Category: Gorrec F]] |
| - | [[Category: Johansson | + | [[Category: Johansson C]] |
| - | [[Category: Papagrigoriou | + | [[Category: Papagrigoriou E]] |
| - | + | [[Category: Savitsky P]] | |
| - | [[Category: Savitsky | + | [[Category: Smee C]] |
| - | [[Category: Smee | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Turnbull A]] |
| - | [[Category: Turnbull | + | [[Category: Ugochukwu E]] |
| - | [[Category: Ugochukwu | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Yang X]] |
| - | [[Category: Yang | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
Crystal Structure of the PDZ Domain from Human RGS-3
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berridge G | Bunkoczi G | Burgess N | Colebrook S | Debreczeni J | Doyle D | Edwards A | Elkins J | Gorrec F | Johansson C | Papagrigoriou E | Savitsky P | Smee C | Sundstrom M | Turnbull A | Ugochukwu E | Weigelt J | Yang X | Von Delft F
