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2i3b

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==Solution Structure of a Human Cancer-Related Nucleoside Triphosphatase==
==Solution Structure of a Human Cancer-Related Nucleoside Triphosphatase==
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<StructureSection load='2i3b' size='340' side='right' caption='[[2i3b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2i3b' size='340' side='right'caption='[[2i3b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2i3b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I3B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2i3b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I3B FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDRT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphatase Nucleoside-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.15 3.6.1.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i3b OCA], [https://pdbe.org/2i3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i3b RCSB], [https://www.ebi.ac.uk/pdbsum/2i3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i3b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i3b OCA], [http://pdbe.org/2i3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i3b RCSB], [http://www.ebi.ac.uk/pdbsum/2i3b PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NTPCR_HUMAN NTPCR_HUMAN] Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.<ref>PMID:17291528</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i3b_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i3b_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i3b ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</div>
</div>
<div class="pdbe-citations 2i3b" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2i3b" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nucleoside triphosphatase|Nucleoside triphosphatase]]
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*[[Sandbox 30008|Sandbox 30008]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Nucleoside-triphosphatase]]
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[[Category: Large Structures]]
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[[Category: Almeida, M S]]
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[[Category: Almeida MS]]
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[[Category: Placzek, W J]]
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[[Category: Placzek WJ]]
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[[Category: Wuthrich, K]]
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[[Category: Wuthrich K]]
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[[Category: Aaa]]
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[[Category: Hydrolase]]
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[[Category: Ntpase]]
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[[Category: Rossmann]]
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Current revision

Solution Structure of a Human Cancer-Related Nucleoside Triphosphatase

PDB ID 2i3b

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