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1z9o

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==1.9 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain in Complex with the Rat ORP1 FFAT Motif==
==1.9 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain in Complex with the Rat ORP1 FFAT Motif==
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<StructureSection load='1z9o' size='340' side='right' caption='[[1z9o]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1z9o' size='340' side='right'caption='[[1z9o]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1z9o]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z9O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1z9o]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z9O FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z9l|1z9l]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Vapa, Vap33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z9o OCA], [https://pdbe.org/1z9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z9o RCSB], [https://www.ebi.ac.uk/pdbsum/1z9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z9o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z9o OCA], [http://pdbe.org/1z9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z9o RCSB], [http://www.ebi.ac.uk/pdbsum/1z9o PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OSBL1_RAT OSBL1_RAT]] Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.[UniProtKB:Q9BXW6]
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[https://www.uniprot.org/uniprot/VAPA_RAT VAPA_RAT] May play a role in vesicle trafficking.<ref>PMID:19289470</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/1z9o_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/1z9o_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z9o ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</div>
<div class="pdbe-citations 1z9o" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1z9o" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Vesicle-associated membrane protein|Vesicle-associated membrane protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Brickner, J H]]
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[[Category: Rattus norvegicus]]
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[[Category: Brunger, A T]]
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[[Category: Brickner JH]]
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[[Category: Fenn, T D]]
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[[Category: Brunger AT]]
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[[Category: Kaiser, S E]]
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[[Category: Fenn TD]]
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[[Category: Reilein, A R]]
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[[Category: Kaiser SE]]
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[[Category: Walter, P]]
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[[Category: Reilein AR]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Walter P]]
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[[Category: Er]]
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[[Category: Erg30]]
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[[Category: Ffat motif]]
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[[Category: Immunoglobulin-like beta sheet]]
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[[Category: Msp homology domain]]
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[[Category: Orp]]
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[[Category: Osbp]]
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[[Category: Oxysterol binding protein]]
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[[Category: Protein binding-lipid binding protein complex]]
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[[Category: Scs2]]
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[[Category: Targeting]]
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[[Category: Vap-33]]
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[[Category: Vap-33a]]
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[[Category: Vap-a]]
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[[Category: Vap-b]]
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[[Category: Vap-c]]
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[[Category: Vapa]]
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[[Category: Vapb]]
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[[Category: Vapc]]
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Current revision

1.9 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain in Complex with the Rat ORP1 FFAT Motif

PDB ID 1z9o

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