1pbr

<StructureSection load='1pbr' size='340' side='right' caption='[[1pbr]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1pbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PBR FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYY:2-DEOXYSTREPTAMINE'>CYY</scene>, <scene name='pdbligand=PA1:2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>PA1</scene>, <scene name='pdbligand=BDR:BETA-D-RIBOFURANOSYL'>BDR</scene>, <scene name='pdbligand=IDG:O-2,6-DIAMINO-2,6-DIDEOXY-BETA-L-IDOPYRANOSE'>IDG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pbr OCA], [http://pdbe.org/1pbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pbr RCSB], [http://www.ebi.ac.uk/pdbsum/1pbr PDBsum]</span></td></tr>

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== Publication Abstract from PubMed ==

Aminoglycoside antibiotics that bind to 30S ribosomal A-site RNA cause misreading of the genetic code and inhibit translocation. The aminoglycoside antibiotic paromomycin binds specifically to an RNA oligonucleotide that contains the 30S subunit A site, and the solution structure of the RNA-paromomycin complex was determined by nuclear magnetic resonance spectroscopy. The antibiotic binds in the major groove of the model A-site RNA within a pocket created by an A-A base pair and a single bulged adenine. Specific interactions occur between aminoglycoside chemical groups important for antibiotic activity and conserved nucleotides in the RNA. The structure explains binding of diverse aminoglycosides to the ribosome, their specific activity against prokaryotic organisms, and various resistance mechanisms, and provides insight into ribosome function.

Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic.,Fourmy D, Recht MI, Blanchard SC, Puglisi JD Science. 1996 Nov 22;274(5291):1367-71. PMID:8910275<ref>PMID:8910275</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1pbr" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Blanchard, S]]

[[Category: Fourmy, D]]

[[Category: Puglisi, J D]]

[[Category: Recht, M I]]

[[Category: Aminoglycoside]]

[[Category: Rna transcript]]