2nvw

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==Crystal sctucture of transcriptional regulator Gal80p from kluyveromymes lactis==
==Crystal sctucture of transcriptional regulator Gal80p from kluyveromymes lactis==
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<StructureSection load='2nvw' size='340' side='right' caption='[[2nvw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2nvw' size='340' side='right'caption='[[2nvw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2nvw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NVW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2nvw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NVW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GAL80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Candida sphaerica])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nvw OCA], [http://pdbe.org/2nvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nvw RCSB], [http://www.ebi.ac.uk/pdbsum/2nvw PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nvw OCA], [https://pdbe.org/2nvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nvw RCSB], [https://www.ebi.ac.uk/pdbsum/2nvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nvw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GAL80_KLULA GAL80_KLULA]] This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar.
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[https://www.uniprot.org/uniprot/GAL80_KLULA GAL80_KLULA] This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/2nvw_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/2nvw_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nvw ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Candida sphaerica]]
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[[Category: Kluyveromyces lactis]]
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[[Category: Holden, H M]]
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[[Category: Large Structures]]
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[[Category: Reece, R J]]
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[[Category: Holden HM]]
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[[Category: Sellick, C A]]
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[[Category: Reece RJ]]
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[[Category: Thoden, J B]]
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[[Category: Sellick CA]]
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[[Category: Galactose metabolism]]
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[[Category: Thoden JB]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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Current revision

Crystal sctucture of transcriptional regulator Gal80p from kluyveromymes lactis

PDB ID 2nvw

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