This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1y1u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:09, 25 October 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of unphosphorylated STAT5a==
==Structure of unphosphorylated STAT5a==
-
<StructureSection load='1y1u' size='340' side='right' caption='[[1y1u]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
+
<StructureSection load='1y1u' size='340' side='right'caption='[[1y1u]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1y1u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1U FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [http://pdbe.org/1y1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [http://www.ebi.ac.uk/pdbsum/1y1u PDBsum]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1u OCA], [https://pdbe.org/1y1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1u RCSB], [https://www.ebi.ac.uk/pdbsum/1y1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/STA5A_MOUSE STA5A_MOUSE]] Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.<ref>PMID:10508857</ref> <ref>PMID:16837552</ref>
+
[https://www.uniprot.org/uniprot/STA5A_MOUSE STA5A_MOUSE] Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.<ref>PMID:10508857</ref> <ref>PMID:16837552</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1u_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1u_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y1u ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 30: Line 32:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Lk3 transgenic mice]]
+
[[Category: Large Structures]]
-
[[Category: Becker, S]]
+
[[Category: Mus musculus]]
-
[[Category: Klumpp, K]]
+
[[Category: Becker S]]
-
[[Category: Neculai, A M]]
+
[[Category: Klumpp K]]
-
[[Category: Neculai, D]]
+
[[Category: Neculai AM]]
-
[[Category: Pfitzner, E]]
+
[[Category: Neculai D]]
-
[[Category: Straub, K]]
+
[[Category: Pfitzner E]]
-
[[Category: Verrier, S]]
+
[[Category: Straub K]]
-
[[Category: Activator]]
+
[[Category: Verrier S]]
-
[[Category: Dna-binding]]
+
-
[[Category: Sh2 domain]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Stat]]
+
-
[[Category: Transcription regulation]]
+

Current revision

Structure of unphosphorylated STAT5a

PDB ID 1y1u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1y1u"
Personal tools