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1t7s

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[[Image:1t7s.gif|left|200px]]
 
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{{Structure
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==Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein==
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|PDB= 1t7s |SIZE=350|CAPTION= <scene name='initialview01'>1t7s</scene>, resolution 2.80&Aring;
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<StructureSection load='1t7s' size='340' side='right'caption='[[1t7s]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[1t7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T7S FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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|GENE= Bag-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00264 BAG], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK07577 PRK07577]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7s OCA], [https://pdbe.org/1t7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t7s RCSB], [https://www.ebi.ac.uk/pdbsum/1t7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t7s ProSAT], [https://www.topsan.org/Proteins/SECSG/1t7s TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7s OCA], [http://www.ebi.ac.uk/pdbsum/1t7s PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1t7s RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/BAG1_CAEEL BAG1_CAEEL] May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t7s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t7s ConSurf].
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<div style="clear:both"></div>
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'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''
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==See Also==
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*[[BAG family proteins 3D structures|BAG family proteins 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.
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==About this Structure==
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1T7S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7S OCA].
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==Reference==
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Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15333932 15333932]
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bunzel, R.]]
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[[Category: Bunzel R]]
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[[Category: Li, S.]]
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[[Category: Li S]]
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[[Category: Luan, C H.]]
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[[Category: Luan C-H]]
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[[Category: Luo, M.]]
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[[Category: Luo M]]
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[[Category: Pruett, P.]]
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[[Category: Pruett P]]
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[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]]
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[[Category: Schormann N]]
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[[Category: Schormann, N.]]
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[[Category: Symersky J]]
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[[Category: Symersky, J.]]
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[[Category: Zhang Y]]
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[[Category: Zhang, Y.]]
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[[Category: bag-1 cochaperone]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: secsg]]
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[[Category: southeast collaboratory for structural genomic]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:06:52 2008''
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Current revision

Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein

PDB ID 1t7s

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