2r9o

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==Cathepsin S complexed with Compound 8==
==Cathepsin S complexed with Compound 8==
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<StructureSection load='2r9o' size='340' side='right' caption='[[2r9o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='2r9o' size='340' side='right'caption='[[2r9o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2r9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2r9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y15:N-[(1S)-2-{[(1R)-2-(BENZYLOXY)-1-CYANO-1-METHYLETHYL]AMINO}-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y15</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r9m|2r9m]], [[2r9n|2r9n]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y15:N-[(1S)-2-{[(1R)-2-(BENZYLOXY)-1-CYANO-1-METHYLETHYL]AMINO}-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y15</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9o OCA], [https://pdbe.org/2r9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9o RCSB], [https://www.ebi.ac.uk/pdbsum/2r9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9o ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9o OCA], [http://pdbe.org/2r9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r9o RCSB], [http://www.ebi.ac.uk/pdbsum/2r9o PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9o_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9o ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin S]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Bekkali, Y]]
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[[Category: Bekkali Y]]
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[[Category: Brown, M L]]
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[[Category: Brown ML]]
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[[Category: Capolino, A]]
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[[Category: Capolino A]]
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[[Category: Crane, K M]]
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[[Category: Crane KM]]
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[[Category: DeTuri, M]]
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[[Category: DeTuri M]]
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[[Category: Emmanuel, M J]]
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[[Category: Emmanuel MJ]]
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[[Category: Freeman, D]]
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[[Category: Freeman D]]
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[[Category: Frye, L L]]
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[[Category: Frye LL]]
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[[Category: Girardot, M]]
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[[Category: Girardot M]]
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[[Category: Grygon, C A]]
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[[Category: Grygon CA]]
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[[Category: Hao, M H]]
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[[Category: Hao M-H]]
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[[Category: Hrapchak, M]]
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[[Category: Hrapchak M]]
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[[Category: Labadia, M E]]
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[[Category: Labadia ME]]
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[[Category: Liu, W]]
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[[Category: Liu W]]
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[[Category: Morwick, T]]
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[[Category: Morwick T]]
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[[Category: Nelson, R]]
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[[Category: Nelson R]]
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[[Category: Peterson, J D]]
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[[Category: Peterson JD]]
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[[Category: Raymond, E L]]
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[[Category: Raymond EL]]
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[[Category: Spero, D M]]
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[[Category: Spero DM]]
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[[Category: Thomson, D S]]
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[[Category: Thomson DS]]
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[[Category: Wang, Y]]
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[[Category: Wang Y]]
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[[Category: Ward, Y D]]
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[[Category: Ward YD]]
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[[Category: White, A]]
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[[Category: White A]]
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[[Category: White, D M]]
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[[Category: White DM]]
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[[Category: Wildeson, J]]
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[[Category: Wildeson J]]
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[[Category: Young, E R.R]]
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[[Category: Young ERR]]
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[[Category: Zindell, R]]
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[[Category: Zindell R]]
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[[Category: Cathepsin]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Lysosome]]
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[[Category: Protease]]
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[[Category: Thiol protease]]
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[[Category: Zymogen]]
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Current revision

Cathepsin S complexed with Compound 8

PDB ID 2r9o

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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