1h08
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | ==CDK2 | + | |
| - | <StructureSection load='1h08' size='340' side='right' caption='[[1h08]], [[Resolution|resolution]] 1.80Å' scene=''> | + | ==CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor== |
| + | <StructureSection load='1h08' size='340' side='right'caption='[[1h08]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1h08]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1h08]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H08 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWP:(2S)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL'>BWP</scene>, <scene name='pdbligand=BYP:(2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL'>BYP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BWP:(2S)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL'>BWP</scene>, <scene name='pdbligand=BYP:(2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL'>BYP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h08 OCA], [https://pdbe.org/1h08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h08 RCSB], [https://www.ebi.ac.uk/pdbsum/1h08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h08 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
| Line 13: | Line 12: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h08_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h08_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h08 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 30: | Line 29: | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Breault | + | [[Category: Breault GA]] |
| - | [[Category: Ellston | + | [[Category: Ellston RPA]] |
| - | [[Category: Green | + | [[Category: Green S]] |
| - | [[Category: James | + | [[Category: James SR]] |
| - | [[Category: Jewsbury | + | [[Category: Jewsbury PJ]] |
| - | [[Category: Midgley | + | [[Category: Midgley CJ]] |
| - | [[Category: Minshull | + | [[Category: Minshull CA]] |
| - | [[Category: Pauptit | + | [[Category: Pauptit RA]] |
| - | [[Category: Pease | + | [[Category: Pease JE]] |
| - | [[Category: Tucker | + | [[Category: Tucker JA]] |
| - | + | ||
| - | + | ||
Current revision
CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor
| |||||||||||
Categories: Homo sapiens | Large Structures | Breault GA | Ellston RPA | Green S | James SR | Jewsbury PJ | Midgley CJ | Minshull CA | Pauptit RA | Pease JE | Tucker JA
