1nq3

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==Crystal structure of the mammalian tumor associated antigen UK114==
==Crystal structure of the mammalian tumor associated antigen UK114==
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<StructureSection load='1nq3' size='340' side='right' caption='[[1nq3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='1nq3' size='340' side='right'caption='[[1nq3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1nq3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/African_dwarf_goat African dwarf goat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1nq3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQ3 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qd9|1qd9]], [[1qu9|1qu9]], [[1jd1|1jd1]], [[1j7h|1j7h]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nq3 OCA], [http://pdbe.org/1nq3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nq3 RCSB], [http://www.ebi.ac.uk/pdbsum/1nq3 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nq3 OCA], [https://pdbe.org/1nq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1nq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nq3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UK114_CAPHI UK114_CAPHI]] Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).
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[https://www.uniprot.org/uniprot/RIDA_CAPHI RIDA_CAPHI] Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.[UniProtKB:P52758] Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.[UniProtKB:P52758]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nq3_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nq3_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nq3 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: African dwarf goat]]
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[[Category: Capra hircus]]
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[[Category: Briand, C]]
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[[Category: Large Structures]]
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[[Category: Deriu, D]]
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[[Category: Briand C]]
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[[Category: Grutter, M G]]
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[[Category: Deriu D]]
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[[Category: Mistiniene, E]]
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[[Category: Grutter MG]]
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[[Category: Naktinis, V]]
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[[Category: Mistiniene E]]
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[[Category: Immune system]]
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[[Category: Naktinis V]]
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[[Category: Metal binding protein]]
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[[Category: Trimer]]
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[[Category: Tumor associated antigen]]
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[[Category: Uk114]]
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[[Category: Yer057c/yil051c/yjgf protein family]]
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Current revision

Crystal structure of the mammalian tumor associated antigen UK114

PDB ID 1nq3

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OCA

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