1o8r

From Proteopedia

(Difference between revisions)

Current revision

Solution structure of human proguanylin

Structural highlights

1o8r is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR, 30 models
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GUC2A_HUMAN Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The endogenous ligand of guanylyl cyclase C, guanylin, is produced as the 94-amino-acid prohormone proguanylin, with the hormone guanylin located at the COOH terminus of the prohormone. The solution structure of proguanylin adopts a new protein fold and consists of a three-helix bundle, a small three-stranded beta-sheet of two NH2-terminal strands and one COOH-terminal strand, and an unstructured linker region. The sequence corresponding to guanylin is fixed in its bioactive topology and is involved in interactions with the NH2-terminal beta-hairpin: the hormone region (residues 80-94) partly wraps around the first 4 NH2-terminal residues that thereby shield parts of the hormone surface. These interactions provide an explanation for the negligible bioactivity of the prohormone as well as the important role of the NH2-terminal residues in the disulfide-coupled folding of proguanylin. Since the ligand binding region of guanylyl cyclase C is predicted to be located around an exposed beta-strand, the intramolecular interactions observed between guanylin and its prosequence may be comparable with the guanylin/receptor interaction.

Solution structure of human proguanylin: the role of a hormone prosequence.,Lauber T, Neudecker P, Rosch P, Marx UC J Biol Chem. 2003 Jun 27;278(26):24118-24. Epub 2003 Apr 21. PMID:12707255^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lauber T, Neudecker P, Rosch P, Marx UC. Solution structure of human proguanylin: the role of a hormone prosequence. J Biol Chem. 2003 Jun 27;278(26):24118-24. Epub 2003 Apr 21. PMID:12707255 doi:http://dx.doi.org/10.1074/jbc.M300370200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o8r"

Categories: Homo sapiens | Large Structures | Lauber T | Marx UC | Rosch P

@@ Line 1: / Line 1: @@
-==SOLUTION STRUCTURE OF HUMAN PROGUANYLIN==
-<StructureSection load='1o8r' size='340' side='right' caption='[[1o8r]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
+==Solution structure of human proguanylin==
+<StructureSection load='1o8r' size='340' side='right'caption='[[1o8r]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1o8r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O8R FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1o8r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O8R FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gna|1gna]], [[1gnb|1gnb]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 30 models</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8r OCA], [http://pdbe.org/1o8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o8r RCSB], [http://www.ebi.ac.uk/pdbsum/1o8r PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8r OCA], [https://pdbe.org/1o8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o8r RCSB], [https://www.ebi.ac.uk/pdbsum/1o8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o8r ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GUC2A_HUMAN GUC2A_HUMAN]] Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
+[https://www.uniprot.org/uniprot/GUC2A_HUMAN GUC2A_HUMAN] Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/1o8r_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/1o8r_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o8r ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 31: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Lauber, T]]
+[[Category: Large Structures]]
-[[Category: Marx, U C]]
+[[Category: Lauber T]]
-[[Category: Rosch, P]]
+[[Category: Marx UC]]
-[[Category: Gap-i]]
+[[Category: Rosch P]]
-[[Category: Guanylin]]
-[[Category: Precursor]]
-[[Category: Proguanylin]]
-[[Category: Prohormone]]
-[[Category: Prosequence]]

1o8r

From Proteopedia

Current revision

Solution structure of human proguanylin

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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