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1n6t

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==Solution Structure of the Tachykinin Peptide Neurokinin A==
==Solution Structure of the Tachykinin Peptide Neurokinin A==
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<StructureSection load='1n6t' size='340' side='right' caption='[[1n6t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1n6t' size='340' side='right'caption='[[1n6t]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1n6t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N6T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1n6t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N6T FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6t OCA], [http://pdbe.org/1n6t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n6t RCSB], [http://www.ebi.ac.uk/pdbsum/1n6t PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6t OCA], [https://pdbe.org/1n6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n6t RCSB], [https://www.ebi.ac.uk/pdbsum/1n6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n6t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TKNB_CHICK TKNB_CHICK]] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
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[https://www.uniprot.org/uniprot/TKNB_CHICK TKNB_CHICK] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of NKA, a decapeptide of mammalian origin, has been characterized by CD spectropolarimetry and 2D proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in both aqueous and membrane mimetic solvents. Unambiguous NMR assignments of protons have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and nuclear Overhauser effect spectroscopy (NOESY and ROESY) experiments. The distance constraints obtained from the NMR data have been utilized to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that in water NKA prefers to be in an extended chain conformation whereas a helical conformation is induced in the central core and the C-terminal region (D4-M10) of the peptide in the presence of perdeuterated dodecylphosphocholine (DPC) micelles, a membrane model system. Though less defined the N-terminus also displays some degree of order and a possible turn structure. The conformation adopted by NKA in the presence of DPC micelles represents a structural motif typical of neurokinin-2 selective agonists and is similar to that reported for eledoisin in hydrophobic environment.
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Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles.,Chandrashekar IR, Cowsik SM Biophys J. 2003 Dec;85(6):4002-11. PMID:14645089<ref>PMID:14645089</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1n6t" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chandrashekar, I R]]
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[[Category: Gallus gallus]]
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[[Category: Cowsik, S M]]
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[[Category: Large Structures]]
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[[Category: 10 helix]]
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[[Category: Chandrashekar IR]]
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[[Category: Dpc micelle]]
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[[Category: Cowsik SM]]
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[[Category: Helix]]
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[[Category: Lipid induced conformation]]
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[[Category: Neuropeptide]]
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Current revision

Solution Structure of the Tachykinin Peptide Neurokinin A

PDB ID 1n6t

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