2r3z

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==Crystal structure of mouse IP-10==
==Crystal structure of mouse IP-10==
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<StructureSection load='2r3z' size='340' side='right' caption='[[2r3z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='2r3z' size='340' side='right'caption='[[2r3z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1o7y|1o7y]], [[1o7z|1o7z]], [[1o80|1o80]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [https://pdbe.org/2r3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [https://www.ebi.ac.uk/pdbsum/2r3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r3z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [http://pdbe.org/2r3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [http://www.ebi.ac.uk/pdbsum/2r3z PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE]] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
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[https://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r3z_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r3z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r3z ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[C-X-C motif chemokine|C-X-C motif chemokine]]
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*[[C-X-C motif chemokine 3D structures|C-X-C motif chemokine 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Acharya, K R]]
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[[Category: Mus musculus]]
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[[Category: Jabeen, T]]
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[[Category: Acharya KR]]
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[[Category: Jamaluddin, H]]
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[[Category: Jabeen T]]
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[[Category: Leonard, P]]
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[[Category: Jamaluddin H]]
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[[Category: Attractant]]
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[[Category: Leonard P]]
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[[Category: Chemokine]]
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[[Category: Chemotaxis]]
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[[Category: Inflammatory response]]
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[[Category: Ip-10/cxcl10]]
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Current revision

Crystal structure of mouse IP-10

PDB ID 2r3z

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OCA

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