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1t1u

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==Structural Insights and Functional Implications of Choline Acetyltransferase==
==Structural Insights and Functional Implications of Choline Acetyltransferase==
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<StructureSection load='1t1u' size='340' side='right' caption='[[1t1u]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='1t1u' size='340' side='right'caption='[[1t1u]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1t1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T1U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1t1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1U FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Chat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1u OCA], [https://pdbe.org/1t1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1u RCSB], [https://www.ebi.ac.uk/pdbsum/1t1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1u ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1u OCA], [http://pdbe.org/1t1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t1u RCSB], [http://www.ebi.ac.uk/pdbsum/1t1u PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLAT_RAT CLAT_RAT]] Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
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[https://www.uniprot.org/uniprot/CLAT_RAT CLAT_RAT] Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1u_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1u_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1u ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Choline O-acetyltransferase]]
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[[Category: Rattus norvegicus]]
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[[Category: Agbandje-McKenna, M]]
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[[Category: Agbandje-McKenna M]]
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[[Category: Govindasamy, L]]
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[[Category: Govindasamy L]]
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[[Category: Gu, Y]]
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[[Category: Gu Y]]
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[[Category: Jin, S]]
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[[Category: Jin S]]
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[[Category: Kukar, T]]
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[[Category: Kukar T]]
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[[Category: Lian, W]]
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[[Category: Lian W]]
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[[Category: Pedersen, B]]
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[[Category: Pedersen B]]
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[[Category: Wu, D]]
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[[Category: Wu D]]
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[[Category: Choline acetyltransferase]]
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[[Category: Transferase]]
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Current revision

Structural Insights and Functional Implications of Choline Acetyltransferase

PDB ID 1t1u

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