1da4

<StructureSection load='1da4' size='340' side='right' caption='[[1da4]], [[NMR_Ensembles_of_Models | 2 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1da4]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DA4 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1da4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1da4 OCA], [http://pdbe.org/1da4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1da4 RCSB], [http://www.ebi.ac.uk/pdbsum/1da4 PDBsum]</span></td></tr>

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== Publication Abstract from PubMed ==

The solution structure of the cis-Pt-GTG adduct in the double-stranded oligomer d(CTCTAGTGCTCAC).td(GTGAGCACTAGAG) was studied with high-resolution NMR techniques. For model building, the distance information obtained from two-dimensional NOE experiments was used in molecular mechanic computations and molecular dynamic structure refinements. The structural distortion upon platination appears to be restricted to the base pairs Pt-G6.C21 and T7.A20; Pt-G8.C19 forms a normal Watson-Crick base pair. T7 is positioned in the minor groove and stacks with the highly propeller-twisted Pt-G6. There is no hydrogen bonding between T7 and A20. The complementary strand is undistorted; A20 stacks with its flanking cytidines (C19 and C21) as in regular B-DNA. The duplex is locally unwound (from base pair A5.T22 to G8.C19: 19 degrees) and is slightly kinked (20 degrees) at the platination site. The platinum coordination distorts the DNA structure at the 5' side of the platinated-GTG-sequence and changes the minor groove face.

The solution structure of a DNA duplex containing the cis-Pt(NH3)2[d(-GTG-)-N7(G),N7(G)] adduct, as determined with high-field NMR and molecular mechanics/dynamics.,van Garderen CJ, van Houte LP Eur J Biochem. 1994 Nov 1;225(3):1169-79. PMID:7957208<ref>PMID:7957208</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1da4" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Garderen, C J.Van]]

[[Category: Houte, L P.A Van]]

[[Category: Dna]]