2an1

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[[Image:2an1.gif|left|200px]]
 
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{{Structure
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==Structural Genomics, The crystal structure of a putative kinase from Salmonella typhimurim LT2==
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|PDB= 2an1 |SIZE=350|CAPTION= <scene name='initialview01'>2an1</scene>, resolution 2.0&Aring;
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<StructureSection load='2an1' size='340' side='right'caption='[[2an1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2an1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AN1 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE= yfjB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2an1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2an1 OCA], [https://pdbe.org/2an1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2an1 RCSB], [https://www.ebi.ac.uk/pdbsum/2an1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2an1 ProSAT], [https://www.topsan.org/Proteins/MCSG/2an1 TOPSAN]</span></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK03378 ppnK]</span>
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2an1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2an1 OCA], [http://www.ebi.ac.uk/pdbsum/2an1 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2an1 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/NADK_SALTY NADK_SALTY] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as a source of phosphorus. NADH can not replace NAD as a substrate.[HAMAP-Rule:MF_00361]<ref>PMID:16682646</ref>
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== Evolutionary Conservation ==
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'''Structural Genomics, The crystal structure of a putative kinase from Salmonella typhimurim LT2'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2an1_consurf.spt"</scriptWhenChecked>
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2AN1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AN1 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: NAD(+) kinase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Salmonella typhimurium]]
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</jmolCheckbox>
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[[Category: Single protein]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2an1 ConSurf].
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[[Category: Collart, F.]]
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<div style="clear:both"></div>
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[[Category: Holzle, D.]]
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== References ==
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[[Category: Joachimiak, A.]]
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<references/>
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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__TOC__
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[[Category: Zhang, R.]]
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</StructureSection>
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[[Category: Zhou, M.]]
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[[Category: Large Structures]]
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[[Category: mcsg]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: midwest center for structural genomic]]
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[[Category: Collart F]]
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[[Category: protein structure initiative]]
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[[Category: Holzle D]]
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[[Category: psi]]
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[[Category: Joachimiak A]]
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[[Category: putative kinase]]
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[[Category: Zhang R]]
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[[Category: structural genomic]]
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[[Category: Zhou M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:20:41 2008''
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Current revision

Structural Genomics, The crystal structure of a putative kinase from Salmonella typhimurim LT2

PDB ID 2an1

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