1nob

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==KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12==
==KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12==
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<StructureSection load='1nob' size='340' side='right' caption='[[1nob]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='1nob' size='340' side='right'caption='[[1nob]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1nob]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ade12 Ade12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NOB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1nob]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_12 Human adenovirus 12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NOB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kac|1kac]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nob OCA], [http://pdbe.org/1nob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nob RCSB], [http://www.ebi.ac.uk/pdbsum/1nob PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nob OCA], [https://pdbe.org/1nob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nob RCSB], [https://www.ebi.ac.uk/pdbsum/1nob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nob ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPIKE_ADE12 SPIKE_ADE12]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
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[https://www.uniprot.org/uniprot/SPIKE_ADE12 SPIKE_ADE12] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/no/1nob_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/no/1nob_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nob ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ade12]]
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[[Category: Human adenovirus 12]]
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[[Category: Bewley, M C]]
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[[Category: Large Structures]]
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[[Category: Flanagan, J M]]
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[[Category: Bewley MC]]
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[[Category: Freimuth, P]]
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[[Category: Flanagan JM]]
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[[Category: Springer, K]]
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[[Category: Freimuth P]]
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[[Category: Zhang, Y B]]
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[[Category: Springer K]]
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[[Category: Receptor binding]]
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[[Category: Zhang YB]]
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[[Category: Viral protein]]
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Current revision

KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12

PDB ID 1nob

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