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1uhs
From Proteopedia
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==Solution structure of mouse homeodomain-only protein HOP== | ==Solution structure of mouse homeodomain-only protein HOP== | ||
| - | <StructureSection load='1uhs' size='340' side='right' caption='[[1uhs | + | <StructureSection load='1uhs' size='340' side='right'caption='[[1uhs]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1uhs]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1uhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhs OCA], [https://pdbe.org/1uhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhs RCSB], [https://www.ebi.ac.uk/pdbsum/1uhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhs ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhs TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhs_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhs_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhs ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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| + | ==See Also== | ||
| + | *[[HOP protein|HOP protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Aoki | + | [[Category: Mus musculus]] |
| - | [[Category: Arakawa | + | [[Category: Aoki M]] |
| - | [[Category: Carninci | + | [[Category: Arakawa T]] |
| - | [[Category: Hayashizaki | + | [[Category: Carninci P]] |
| - | [[Category: Hirota | + | [[Category: Hayashizaki Y]] |
| - | [[Category: Inoue | + | [[Category: Hirota H]] |
| - | [[Category: Kawai | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kawai J]] |
| - | [[Category: Koshiba | + | [[Category: Kigawa T]] |
| - | [[Category: Matsuda | + | [[Category: Koshiba S]] |
| - | [[Category: Osanai | + | [[Category: Matsuda T]] |
| - | + | [[Category: Osanai T]] | |
| - | [[Category: Saito | + | [[Category: Saito K]] |
| - | [[Category: Seki | + | [[Category: Seki E]] |
| - | [[Category: Shirouzu | + | [[Category: Shirouzu M]] |
| - | [[Category: Tanaka | + | [[Category: Tanaka A]] |
| - | [[Category: Terada | + | [[Category: Terada T]] |
| - | [[Category: Yabuki | + | [[Category: Yabuki T]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
| - | [[Category: Yoshida | + | [[Category: Yoshida M]] |
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Current revision
Solution structure of mouse homeodomain-only protein HOP
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Categories: Large Structures | Mus musculus | Aoki M | Arakawa T | Carninci P | Hayashizaki Y | Hirota H | Inoue M | Kawai J | Kigawa T | Koshiba S | Matsuda T | Osanai T | Saito K | Seki E | Shirouzu M | Tanaka A | Terada T | Yabuki T | Yokoyama S | Yoshida M
