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2b25
From Proteopedia
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==Human putative tRNA(1-methyladenosine)methyltransferase== | ==Human putative tRNA(1-methyladenosine)methyltransferase== | ||
| - | <StructureSection load='2b25' size='340' side='right' caption='[[2b25]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='2b25' size='340' side='right'caption='[[2b25]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2b25]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2b25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B25 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b25 OCA], [https://pdbe.org/2b25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b25 RCSB], [https://www.ebi.ac.uk/pdbsum/2b25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b25 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TR61B_HUMAN TR61B_HUMAN] Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC).<ref>PMID:23097428</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b25_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b25_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b25 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bochkarev | + | [[Category: Arrowsmith C]] |
| - | [[Category: Dong | + | [[Category: Bochkarev A]] |
| - | [[Category: Edwards | + | [[Category: Dong A]] |
| - | [[Category: Loppnau | + | [[Category: Edwards A]] |
| - | [[Category: Plotnikov | + | [[Category: Loppnau P]] |
| - | + | [[Category: Plotnikov AN]] | |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Tempel | + | [[Category: Tempel W]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Wu | + | [[Category: Wu H]] |
| - | [[Category: Zeng | + | [[Category: Zeng H]] |
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Current revision
Human putative tRNA(1-methyladenosine)methyltransferase
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bochkarev A | Dong A | Edwards A | Loppnau P | Plotnikov AN | Sundstrom M | Tempel W | Weigelt J | Wu H | Zeng H
