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2ftp

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[[Image:2ftp.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa==
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|PDB= 2ftp |SIZE=350|CAPTION= <scene name='initialview01'>2ftp</scene>, resolution 2.40&Aring;
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<StructureSection load='2ftp' size='340' side='right'caption='[[2ftp]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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<table><tr><td colspan='2'>[[2ftp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FTP FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_lyase Hydroxymethylglutaryl-CoA lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.4 4.1.3.4] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK05692 PRK05692]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ftp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftp OCA], [https://pdbe.org/2ftp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ftp RCSB], [https://www.ebi.ac.uk/pdbsum/2ftp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ftp ProSAT], [https://www.topsan.org/Proteins/MCSG/2ftp TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ftp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftp OCA], [http://www.ebi.ac.uk/pdbsum/2ftp PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2ftp RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/LIUE_PSEAE LIUE_PSEAE] Involved in the L-leucine, isovalerate and acyclic monoterpene catabolism. Catalyzes the cleavage of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to yield acetyl-CoA and acetoacetate. It can also catalyze the cleavage of 3-hydroxy-3-isohexenylglutaryl-CoA (HIHG_CoA) to yield 7-methyl-3-oxooct-6-enoyl-CoA and acetate.<ref>PMID:19459965</ref> <ref>PMID:19597963</ref>
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'''Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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2FTP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTP OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ftp_consurf.spt"</scriptWhenChecked>
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[[Category: Hydroxymethylglutaryl-CoA lyase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Pseudomonas aeruginosa pao1]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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[[Category: Edwards, A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ftp ConSurf].
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[[Category: Evdokimova, E.]]
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<div style="clear:both"></div>
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[[Category: Kudritska, M.]]
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== References ==
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[[Category: Liu, Y.]]
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<references/>
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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__TOC__
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[[Category: Pai, E F.]]
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</StructureSection>
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[[Category: Savchenko, A.]]
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[[Category: Large Structures]]
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[[Category: Xiao, T.]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: lyase]]
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[[Category: Edwards A]]
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[[Category: mcsg]]
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[[Category: Evdokimova E]]
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[[Category: midwest center for structural genomic]]
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[[Category: Kudritska M]]
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[[Category: protein structure initiative]]
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[[Category: Liu Y]]
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[[Category: psi]]
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[[Category: Pai EF]]
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[[Category: structural genomic]]
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[[Category: Savchenko A]]
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[[Category: Xiao T]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:25:29 2008''
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Current revision

Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa

PDB ID 2ftp

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