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2jkf

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==PLASMODIUM FALCIPARUM PROFILIN==
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<StructureSection load='2jkf' size='340' side='right' caption='[[2jkf]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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==Plasmodium falciparum profilin==
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<StructureSection load='2jkf' size='340' side='right'caption='[[2jkf]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JKF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JKF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jkg|2jkg]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkf OCA], [http://pdbe.org/2jkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jkf RCSB], [http://www.ebi.ac.uk/pdbsum/2jkf PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkf OCA], [https://pdbe.org/2jkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jkf RCSB], [https://www.ebi.ac.uk/pdbsum/2jkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jkf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PROF_PLAF7 PROF_PLAF7]] Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers (By similarity).[UniProtKB:P86294]
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[https://www.uniprot.org/uniprot/PROF_PLAFX PROF_PLAFX] Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers.<ref>PMID:19000816</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkf_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkf_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jkf ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Profilin|Profilin]]
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*[[Profilin 3D Structures|Profilin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plafa]]
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[[Category: Large Structures]]
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[[Category: Ganter, M]]
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[[Category: Kursula, I]]
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[[Category: Kursula, P]]
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[[Category: Matuschewski, K]]
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[[Category: Panjikar, S]]
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[[Category: Schueler, H]]
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[[Category: Actin filament structural protein]]
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[[Category: Cytoskeleton]]
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[[Category: Malaria]]
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Profilin]]
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[[Category: Ganter M]]
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[[Category: Proline-rich ligand]]
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[[Category: Kursula I]]
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[[Category: Protein-binding]]
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[[Category: Kursula P]]
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[[Category: Matuschewski K]]
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[[Category: Panjikar S]]
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[[Category: Schueler H]]

Current revision

Plasmodium falciparum profilin

PDB ID 2jkf

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