2jhy

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==CRYSTAL STRUCTURE OF RHOGDI E155H, E157H MUTANT==
==CRYSTAL STRUCTURE OF RHOGDI E155H, E157H MUTANT==
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<StructureSection load='2jhy' size='340' side='right' caption='[[2jhy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='2jhy' size='340' side='right'caption='[[2jhy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jhy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JHY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jhy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHY FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cc0|1cc0]], [[1fso|1fso]], [[1fst|1fst]], [[1ft0|1ft0]], [[1ft3|1ft3]], [[1hh4|1hh4]], [[1kmt|1kmt]], [[1qvy|1qvy]], [[1rho|1rho]], [[2bxw|2bxw]], [[2jhs|2jhs]], [[2jht|2jht]], [[2jhu|2jhu]], [[2jhv|2jhv]], [[2jhw|2jhw]], [[2jhx|2jhx]], [[2jhz|2jhz]], [[2ji0|2ji0]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhy OCA], [http://pdbe.org/2jhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jhy RCSB], [http://www.ebi.ac.uk/pdbsum/2jhy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhy OCA], [https://pdbe.org/2jhy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhy RCSB], [https://www.ebi.ac.uk/pdbsum/2jhy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhy ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhy_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhy_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jhy ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cooper, D R]]
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[[Category: Large Structures]]
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[[Category: Derewenda, Z S]]
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[[Category: Cooper DR]]
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[[Category: Zawadzki, M]]
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[[Category: Derewenda ZS]]
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[[Category: Crystal engineering]]
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[[Category: Zawadzki M]]
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[[Category: Gtpase activation]]
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[[Category: Inhibitor]]
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[[Category: Surface entropy reduction]]
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CRYSTAL STRUCTURE OF RHOGDI E155H, E157H MUTANT

PDB ID 2jhy

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