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2hc9

From Proteopedia

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[[Image:2hc9.gif|left|200px]]
 
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{{Structure
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==Structure of Caenorhabditis elegans leucine aminopeptidase-zinc complex (LAP1)==
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|PDB= 2hc9 |SIZE=350|CAPTION= <scene name='initialview01'>2hc9</scene>, resolution 1.85&Aring;
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<StructureSection load='2hc9' size='340' side='right'caption='[[2hc9]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2hc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HC9 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucyl_aminopeptidase Leucyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.1 3.4.11.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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|GENE= lap-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00433 Peptidase_M17]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hc9 OCA], [https://pdbe.org/2hc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hc9 RCSB], [https://www.ebi.ac.uk/pdbsum/2hc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hc9 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hc9 TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hc9 OCA], [http://www.ebi.ac.uk/pdbsum/2hc9 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2hc9 RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/AMPL_CAEEL AMPL_CAEEL] Probably acts as a digestive enzyme.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/2hc9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hc9 ConSurf].
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<div style="clear:both"></div>
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'''Structure of Caenorhabditis elegans leucine aminopeptidase-zinc complex (LAP1)'''
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==See Also==
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2HC9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HC9 OCA].
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Leucyl aminopeptidase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Almo SC]]
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[[Category: Almo, S C.]]
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[[Category: Burley SK]]
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[[Category: Burley, S K.]]
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[[Category: Milstein S]]
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[[Category: Milstein, S.]]
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[[Category: Patskovsky Y]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Ramagopal U]]
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[[Category: Patskovsky, Y.]]
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[[Category: Vidal M]]
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[[Category: Ramagopal, U.]]
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[[Category: Wengerter BC]]
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[[Category: Vidal, M.]]
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[[Category: Zhan C]]
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[[Category: Wengerter, B C.]]
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[[Category: Zhan, C.]]
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[[Category: aminopeptidase]]
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[[Category: carbonate]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: peptidase]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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[[Category: zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:28:36 2008''
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Current revision

Structure of Caenorhabditis elegans leucine aminopeptidase-zinc complex (LAP1)

PDB ID 2hc9

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