User:Gabriel Pons/Sandbox 3
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='''TGFβ signalling pathway'''= | ='''TGFβ signalling pathway'''= | ||
| - | <StructureSection load=' | + | <StructureSection load='1klc' size='400' side='right' scene='41/416407/TGF beta/1' caption='General View (PDB code 1klc)'> |
The TGFbeta signalling pathway has an impact on a variety of cellular processes including cell proliferation, differentiation, apoptosis, growth, development, adhesion, neuronal growth, immune surveillance, tissue homeostasis and many others. Moreover, dysregulation of the normal functioning of any element is associated with pathological conditions, such as autoimmune and inflammatory diseases, cancer and cardiovascular diseases | The TGFbeta signalling pathway has an impact on a variety of cellular processes including cell proliferation, differentiation, apoptosis, growth, development, adhesion, neuronal growth, immune surveillance, tissue homeostasis and many others. Moreover, dysregulation of the normal functioning of any element is associated with pathological conditions, such as autoimmune and inflammatory diseases, cancer and cardiovascular diseases | ||
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[[Image:overview.jpg]] | [[Image:overview.jpg]] | ||
=='''Ligands'''== | =='''Ligands'''== | ||
| - | <scene name='41/416407/Tgfbeta-1/1'> TGFβ Superfamily of cytokines</scene> | + | <scene name='41/416407/Tgfbeta-1/1'> TGFβ Superfamily of cytokines</scene> |
| + | The TGFbeta superfamily of cytokines can be divided in two major ligand subfamilies by sequence similarities. On one hand TGFbeta/Inhibin/Nodal/Activin subfamily and on the other hand BMP (Bone Morphogenetic Protein)/AMH (Anti-Müllerian Hormone)/GDF (Growth and Differentiation Factor) subfamily. As shown here <scene name='41/416407/Tgfbeta-bmp7/1'>TgF beta in comparison with BMP-7</scene> , the members of the superfamily share a high conserved tridimensional structure | ||
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===''' TGFβ isoforms'''=== | ===''' TGFβ isoforms'''=== | ||
Current revision
TGFβ signalling pathway
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