4yu7

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==Crystal structure of Piratoxin I (PrTX-I) complexed to caffeic acid==
==Crystal structure of Piratoxin I (PrTX-I) complexed to caffeic acid==
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<StructureSection load='4yu7' size='340' side='right' caption='[[4yu7]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='4yu7' size='340' side='right'caption='[[4yu7]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_pirajai Bothrops pirajai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YU7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yu7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_pirajai Bothrops pirajai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YU7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.647&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yu7 OCA], [http://pdbe.org/4yu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4yu7 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yu7 OCA], [https://pdbe.org/4yu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yu7 RCSB], [https://www.ebi.ac.uk/pdbsum/4yu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yu7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA2H1_BOTPI PA2H1_BOTPI]] Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity, but displays myotoxin and edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid (RA).<ref>PMID:7660366</ref> <ref>PMID:22205953</ref>
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[https://www.uniprot.org/uniprot/PA2H1_BOTPI PA2H1_BOTPI] Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity, but displays myotoxin and edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid (RA).<ref>PMID:7660366</ref> <ref>PMID:22205953</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yu7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yu7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase A2 homolog|Phospholipase A2 homolog]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bothrops pirajai]]
[[Category: Bothrops pirajai]]
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[[Category: Fernandes, C A.H]]
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[[Category: Large Structures]]
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[[Category: Fontes, M R.M]]
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[[Category: Fernandes CAH]]
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[[Category: Phospholipase a2 phospholipase a2-like bothrops snake venom inhibitor]]
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[[Category: Fontes MRM]]
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[[Category: Toxin]]
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Current revision

Crystal structure of Piratoxin I (PrTX-I) complexed to caffeic acid

PDB ID 4yu7

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